Targeting miRNAs in osteoblast differentiation and bone formation

被引：87

作者：

Hu, Rong ^{[1
]}

Li, Hui ^{[1
]}

Liu, Wei ^{[1
]}

Yang, Li ^{[1
]}

Tan, Yan-Fei ^{[1
]}

Luo, Xiang-Hang ^{[1
]}

机构：

[1] Cent S Univ, Xiangya Hosp 2, Inst Endocrinol & Metab, Changsha 410011, Hunan, Peoples R China

来源：

EXPERT OPINION ON THERAPEUTIC TARGETS | 2010年 / 14卷 / 10期

关键词：

antagomirs; bone biology; mesenchymal stromal cells; miRNA; miRNA profiling; osteoblast differentiation; target prediction; MICRORNA EXPRESSION PROFILES; GROWTH-FACTOR-BETA; GENE-EXPRESSION; ANTISENSE OLIGONUCLEOTIDES; OSTEOGENIC DIFFERENTIATION; INTERFERING RNAS; DOWN-REGULATION; STROMAL CELLS; STEM-CELLS; IN-VITRO;

D O I：

10.1517/14728222.2010.512916

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Importance of the field: Bone tissue arises from mesenchymal stromal cells (MSCs) differentiated into the osteoblast lineage by genetic and epigenetic mechanisms. Emerging evidence indicates that the class of small non-coding single-stranded RNAs known as "microRNAs (miRNAs)" also plays a critical role in this process. Areas covered in this review: In this short review, we summarize the biology and functional mechanisms of miRNAs. Importantly, we discuss miRNA expression, miRNA function, miRNA target prediction, miRNA overexpression and inhibition methods applied in osteoblastogenesis. What the reader will gain: We discuss the potential therapeutic opportunities and challenges for improving the treatment of bone-related diseases by using miRNAs as a therapeutic target. Take home message: Although various microRNAs regulate cell proliferation and differentiation, only a few miRNAs has been reported so far to play a key role in the regulation of osteoblast differentiation and bone formation.

引用

页码：1109 / 1120

页数：12

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