Three-Dimensional Chemical Patterns for Cellular Self-Organization

被引：20

作者：

Kalinin, Yevgeniy V. ^{[1
]}

Randhawa, Jatinder S. ^{[1
]}

Gracias, David H. ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 11期

关键词：

chemical patterning; chemotaxis; drug delivery; self-assembly; tissue engineering; COMPLEX GRADIENTS; MIGRATION; MICROSPHERES; CHEMISTRY; BLOCKING; RELEASE; CELLS;

D O I：

10.1002/anie.201007107

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Falling into line: A method for the precise generation of durable 3D chemical patterns within stationary media was used to direct the chemotactic self-organization of living cells. A container with carefully positioned slits, through which a chemoattractant (yellow) can diffuse, controls the self-organization of Escherichia coli cells (green ellipsoids) expressing green fluorescent protein into a helical pattern (see fluorescence images). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2549 / 2553

页数：5

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