Pleiotropic changes controlled by the pre-T-cell receptor

被引：164

作者：

von Boehmer, H ^{[1
]}

Aifantis, I ^{[1
]}

Feinberg, J ^{[1
]}

Lechner, O ^{[1
]}

Saint-Ruf, C ^{[1
]}

Walter, U ^{[1
]}

Buer, J ^{[1
]}

Azogui, O ^{[1
]}

机构：

[1] Fac Med Necker Enfants Malad, INSERM, U373, Inst Necker, F-75730 Paris 15, France

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(99)80024-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The construction of various gene-deificient mice has facilitated the understanding of the role of various receptors and signaling pathways that control the generation of alpha beta lineage cells. A predominant role is occupied by the pre-TCR, which not only generates large numbers of alpha beta lineage cells but also controls TCR beta allelic exclusion as well as commitment to the gamma delta lineage versus the alpha beta lineage.

引用

页码：135 / 142

页数：8

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