Clinical and Laboratory Characteristics of Clostridium difficile Infection in Patients with Discordant Diagnostic Test Results

被引：49

作者：

Kaltsas, Anna ^{[1
]}

Simon, Matt ^{[2
]}

Unruh, Larissa H. ^{[3
]}

Son, Crystal ^{[1
]}

Wroblewski, Danielle ^{[4
]}

Musser, Kimberlee A. ^{[4
]}

Sepkowitz, Kent ^{[1
]}

Babady, N. Esther ^{[1
]}

Kamboj, Mini ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

[2] New York Presbyterian Hosp Weill Cornell, New York, NY USA

[3] Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA

[4] New York State Dept Hlth, Wadsworth Ctr, Albany, NY USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2012年 / 50卷 / 04期

关键词：

REAL-TIME PCR; TOXIN PRODUCTION; STRAIN; AMERICA; DISEASE; ASSAY; TCDC;

D O I：

10.1128/JCM.05711-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The aim of this study was to compare the clinical and laboratory characteristics of Clostridium difficile infection (CDI) in patients with discordant test results for the cytotoxin assay (CYT) and PCR assays. A retrospective study from May to August 2008 and March to May 2010 was performed. CDI was diagnosed in 128 patients. PCR increased the yield of C. difficile cases by 2-fold compared to that of the CYT assay. Fifty-six cases (44%) were detected by PCR only (CYT negative). Forty-nine percent of patients with non-NAP1 strains were detected by PCR only, compared to 28% of those infected with NAP1 strains (P < 0.05). No significant differences were found in the clinical severity of illness and outcome among patients that tested positive for CDI by both tests (CYT and PCR) compared to those that tested positive by PCR only.

引用

页码：1303 / 1307

页数：5

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