Antifungal activity of coronarin D against Candida albicans

被引：21

作者：

Kaomongkolgit, Ruchadaporn ^{[1
]}

Jamdee, Kusuma ^{[2
]}

Wongnoi, Sorapong ^{[2
]}

Chimnoi, Nitirat ^{[3
]}

Techasakul, Supanna ^{[3
,4
]}

机构：

[1] Naresuan Univ, Fac Dent, Dept Oral Diag, Phitsanulok 65000, Thailand

[2] Naresuan Univ, Fac Dent, Dent Sci Res Ctr, Phitsanulok 65000, Thailand

[3] Chulabhorn Res Inst, Bangkok, Thailand

[4] Kasetsart Univ, Fac Sci, Ctr Innovat Chem, Dept Chem, Bangkok, Thailand

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY | 2012年 / 114卷 / 01期

关键词：

ORAL FUNGAL-INFECTIONS; HEDYCHIUM-CORONARIUM; OROPHARYNGEAL CANDIDIASIS; DITERPENES; INHIBITION; RHIZOMES; THERAPY; OIL;

D O I：

10.1016/j.oooo.2012.01.010

中图分类号：

R78 [口腔科学];

学科分类号：

100302 [口腔临床医学];

摘要：

Objective. The objective of this study was to investigate the antifungal activity of coronarin D on Candida albicans and its activity was compared with clotrimazole and nystatin. Methods. Coronarin D was extracted by liquid chromatography and used in antifungal testing. The inhibitory effect of coronarin D on C. albicans was determined by cultures and an applied broth dilution test. The rate of fungicidal activity was evaluated by time-kill curves. Morphologic alterations of fungal cells were investigated using scanning electron microscopy. Results. Coronarin D was effective against C. albicans; the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were 2 and 4 mg/mL, respectively. The C. albicans killing activity of coronarin D was higher than clotrimazole and nystatin at 2 x MFC and 4 x MFC, respectively. Morphologic alterations of fungal cells consistent with cell membrane damage were observed in the coronarin D-treated cells. Conclusions. Coronarin D showed promising antifungal activity against C. albicans in vitro. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:61-66)

引用

页码：61 / 66

页数：6

共 30 条

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