Expanding chemical biology of 2-oxoglutarate oxygenases

被引：408

作者：

Loenarz, Christoph ^{[1
]}

Schofield, Christopher J. ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Oxford Ctr Integrat Syst Biol, Oxford OX1 3TA, England

来源：

NATURE CHEMICAL BIOLOGY | 2008年 / 4卷 / 03期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1038/nchembio0308-152

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Beyond established roles in collagen biosynthesis, hypoxic signaling and fatty acid metabolism, recent reports have now revealed roles for human 2-oxoglutarate-dependent oxygenases in histone and nucleic acid demethylation and in signaling protein hydroxylation. The emerging role of these oxygenases in enabling a multiplicity of histone modifications has some analogy with their role in enabling structural diversity in secondary metabolism.

引用

页码：152 / 156

页数：5

共 30 条

[1] UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development [J].

Agger, Karl ;

Cloos, Paul A. C. ;

Christensen, Jesper ;

Pasini, Diego ;

Rose, Simon ;

Rappsilber, Juri ;

Issaeva, Irina ;

Canaani, Eli ;

Salcini, Anna Elisabetta ;

Helin, Kristian .

NATURE, 2007, 449 (7163) :731-U10

[2]

Bose Jens, 2004, J Biol, V3, P15, DOI 10.1186/jbiol10

[3] JMJD6 is a histone arginine demethylase [J].

Chang, Bingsheng ;

Chen, Yue ;

Zhao, Yingming ;

Bruick, Richard K. .

SCIENCE, 2007, 318 (5849) :444-447

[4] Aminoacyl-S-enzyme intermediates in β-hydroxylations and α,β-desaturations of amino acids in peptide antibiotics [J].

Chen, HW ;

Thomas, MG ;

O'Connor, SE ;

Hubbard, BK ;

Burkart, MD ;

Walsh, CT .

BIOCHEMISTRY, 2001, 40 (39) :11651-11659

[5] Structural basis of the recognition of a methylated histone tail by JMJD2A [J].

Chen, Zhongzhou ;

Zang, Jianye ;

Kappler, John ;

Hong, Xia ;

Crawford, Frances ;

Wang, Qin ;

Lan, Fei ;

Jiang, Chengyu ;

Whetstine, Johnathan ;

Dai, Shaodong ;

Hansen, Kirk ;

Shi, Yang ;

Zhang, Gongyi .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (26) :10818-10823

[6] The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity -: art. no. 26 [J].

Cikala, M ;

Alexandrova, O ;

David, CN ;

Pröschel, M ;

Stiening, B ;

Cramer, P ;

Böttger, A .

BMC CELL BIOLOGY, 2004, 5 (1)

[7] Structural studies on 2-oxoglutarate oxygenases and related double-stranded β-helix fold proteins [J].

Clifton, Ian J. ;

McDonough, Michael A. ;

Ehrismann, Dominic ;

Kershaw, Nadia J. ;

Granatino, Nicolas ;

Schofield, Christopher J. .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2006, 100 (04) :644-669

[8] Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH) [J].

Cockman, Matthew E. ;

Lancaster, David E. ;

Stolze, Ineke P. ;

Hewitson, Kirsty S. ;

McDonough, Michael A. ;

Coleman, Mathew L. ;

Coles, Charlotte H. ;

Yu, Xiaohong ;

Hay, Ronald T. ;

Ley, Steven C. ;

Pugh, Christopher W. ;

Oldham, Neil J. ;

Masson, Norma ;

Schofield, Christopher J. ;

Ratcliffe, Peter J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (40) :14767-14772

[9]

Coleman ML, 2007, ESSAYS BIOCHEM, V43, P1

[10] Asparaginyl hydroxylation of the notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor [J].

Coleman, Mathew L. ;

McDonough, Michael A. ;

Hewitson, Kirsty S. ;

Coles, Charlotte ;

Mecinovic, Jasmin ;

Edelmann, Mariola ;

Cook, Kristina M. ;

Cockman, Matthew E. ;

Lancaster, David E. ;

Kessler, Benedikt M. ;

Oldham, Neil J. ;

Ratcliffe, Peter J. ;

Schofield, Christopher J. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (33) :24027-24038

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