Structure of proteins involved in synaptic vesicle fusion in neurons

被引：39

作者：

Brunger, AT ^{[1
]}

机构：

[1] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Mol & Cellular Physiol Neurol & Neurol Sci, Stanford, CA 94305 USA

[3] Stanford Univ, Stanford Synchrotron Radiat Lab, Stanford, CA 94305 USA

来源：

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE | 2001年 / 30卷

关键词：

exocytosis; vesicle fusion; neurotransmission; coiled coils; chaperone;

D O I：

10.1146/annurev.biophys.30.1.157

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fusion of vesicles with target membranes is controlled by a complex network of protein-protein and protein-lipid interactions. Structures of the SNARE complex, synaptotagmin III, nSec 1, domains of the NSF chaperone and its adaptor SNAP, and Rab3 and some of its effecters provide the framework for developing molecular models of vesicle fusion and for designing experiments to test these models.

引用

页码：157 / 171

页数：17

共 104 条

[1] Crystal structure of the Sec18p N-terminal domain
Babor, SM
Fass, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) : 14759 - 14764
[2] THE MOLECULAR MACHINERY FOR SECRETION IS CONSERVED FROM YEAST TO NEURONS
BENNETT, MK
SCHELLER, RH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (07) : 2559 - 2563
[3] Beyer A, 1997, PROTEIN SCI, V6, P2043
[4] SNARE proteins mediate lipid bilayer fusion
Bock, JB
Scheller, RH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (22) : 12227 - 12229
[5] INTERACTIONS OF 3 DOMAINS DISTINGUISHING THE RAS-RELATED GTP-BINDING PROTEINS YPT1 AND SEC4
BRENNWALD, P
NOVICK, P
[J]. NATURE, 1993, 362 (6420) : 560 - 563
[6] SYNAPTOTAGMIN - A CALCIUM SENSOR ON THE SYNAPTIC VESICLE SURFACE
BROSE, N
PETRENKO, AG
SUDHOF, TC
JAHN, R
[J]. SCIENCE, 1992, 256 (5059) : 1021 - 1025
[7] Sec1p binds to SNARE complexes and concentrates at sites of secretion
Carr, CM
Grote, E
Munson, M
Hughson, FM
Novick, PJ
[J]. JOURNAL OF CELL BIOLOGY, 1999, 146 (02) : 333 - 344
[8] Rab3A is essential for mossy fibre long-term potentiation in the hippocampus
Castillo, PE
Janz, R
Sudhof, TC
Tzounopoulos, T
Malenka, RC
Nicoll, RA
[J]. NATURE, 1997, 388 (6642) : 590 - 593
[9] Lipid binding ridge on loops 2 and 3 of the C2A domain of synaptotagmin I as revealed by NMR spectroscopy
Chae, YK
Abildgaard, F
Chapmann, ER
Markley, JL
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (40) : 25659 - 25663
[10] Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin
Chapman, ER
Desai, RC
Davis, AF
Tornehl, CK
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (49) : 32966 - 32972

← 1 2 3 4 5 6 7 8 9 10 →