Two new point mutations at A2062 associated with resistance to 16-membered macrolide antibiotics in mutant strains of Mycoplasma hominis

被引：29

作者：

Furneri, PM

Rappazzo, G

Musumarra, MP

Di Pietro, P

Catania, LS

Roccasalva, LS

机构：

[1] Univ Catania, Dipartimento Sci Microbiol & Sci Ginecol, I-95124 Catania, Italy

[2] Univ Catania, Dipartimento Biol Anim, Catania, Italy

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 10期

关键词：

D O I：

10.1128/AAC.45.10.2958-2960.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We describe two mutants of Mycoplasma hominis PG-21 which show resistance to 16-membered macrolides but susceptibility to lincosamides, obtained by in vitro exposure to increasing doses of josamycin. The 23S rRNA gene showed that each had a mutation (A2062G and A2062T) corresponding to nucleotide 2062 in Escherichia coli, which was associated with the acquired phenotype.

引用

页码：2958 / 2960

页数：3

共 35 条

[31] INVITRO SUSCEPTIBILITIES OF MYCOPLASMA-PNEUMONIAE, MYCOPLASMA-HOMINIS, AND UREAPLASMA-UREALYTICUM TO SPARFLOXACIN AND PD-127391 [J].