Immunology of Chlamydia infection:: Implications for a Chlamydia trachomatis vaccine

被引:461
作者
Brunham, RC [1 ]
Rey-Ladino, J [1 ]
机构
[1] Univ British Columbia, Ctr Dis Control, Vancouver, BC V5Z 4R4, Canada
基金
加拿大健康研究院;
关键词
D O I
10.1038/nri1551
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Sexually transmitted Chlamydia trachomatis infections are a serious public-health problem. With more than 90 million new cases occurring annually, C. trachomatis is the most common cause of bacterial sexually transmitted disease worldwide. Recent progress in elucidating the immunobiology of Chlamydia muridarum infection of mice has helped to guide the interpretation of immunological findings in studies of human C. trachomatis infection and has led to the development of a common model of immunity. In this review, we describe our current understanding of the immune response to infection with Chlamydia spp. and how this information is improving the prospects for development of a vaccine against infection with C. trachomatis.
引用
收藏
页码:149 / 161
页数:13
相关论文
共 144 条
[141]   Priming with Chlamydia trachomatis major outer membrane protein (MOMP) DNA followed by MOMP ISCOM boosting enhances protection and is associated with increased immunoglobulin A and Th1 cellular immune responses [J].
Zhang, DJ ;
Yang, X ;
Shen, CX ;
Lu, H ;
Murdin, A ;
Brunham, RC .
INFECTION AND IMMUNITY, 2000, 68 (06) :3074-3078
[142]   DNA vaccination with the major outer-membrane protein gene induces acquired immunity to Chlamydia trachomatis (mouse pneumonitis) infection [J].
Zhang, DJ ;
Yang, X ;
Berry, J ;
Shen, CX ;
McClarty, G ;
Brunham, RC .
JOURNAL OF INFECTIOUS DISEASES, 1997, 176 (04) :1035-1040
[143]   Degradation of transcription factor RFX5 during the inhibition of both constitutive and interferon γ-inducible major histocompatibility complex class I expression in Chlamydia-infected cells [J].
Zhong, GM ;
Liu, L ;
Fan, T ;
Fan, PY ;
Ji, HZ .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (09) :1525-1534
[144]   Nasal-associated lymphoid tissue is a mucosal inductive site for virus-specific humoral and cellular immune responses [J].
Zuercher, AW ;
Coffin, SE ;
Thurnheer, MC ;
Fundova, P ;
Cebra, JJ .
JOURNAL OF IMMUNOLOGY, 2002, 168 (04) :1796-1803