Estrogen improves endothelial function - Discussion

被引:82
作者
Donaldson, MC
Arora, S
Kaufman, JL
Cronenwett, JL
McDaniel, MD
Whittmore, A
Babson, WW
机构
[1] Beth Israel Deaconess Medical Center, West Campus, Boston, MA 02215
关键词
D O I
10.1016/S0741-5214(98)70016-3
中图分类号
R61 [外科手术学];
学科分类号
摘要
Purpose: To determine the effect of estrogen on endothelium-dependent relaxation in the cutaneous microcirculation of women. Methods: Three groups of women participated in the study. Group 1 (n = 20) was premenopausal and had a mean age of 39 years (range 24-50 years). Group 2 (n = 9) was postmenopausal and had a mean age of 58 years (range 53-65 years). Group 3 (n = 11) was postmenopausal and taking estrogen replacement therapy; the mean age was 53 years (range 43-58 years). Eleven women in group 1 underwent testing twice, once during menstruation (mean serum estradiol level 73 ± 30 pg/ml) and once during midcycle (mean serum estradiol level 268 ± 193 pg/ml; p = 0.003). Single-point laser Doppler ultrasound and laser Doppler imaging with a scanner were used to measure vasodilatation in the forearm skin in response to iontophoresis of 1% acetylcholine (endothelium dependent) and 1% sodium nitroprusside (endothelium-independent smooth muscle relaxant). Results: All three groups were matched for body mass index and fasting glucose, total, high-density lipoprotein, and low-density lipoprotein cholesterol and triglyceride levels. All women had normal blood pressure, and none smoked. Mean serum estradiol levels were 196 ± 170 pg/ml (group 1), 35 ± 12 pg/ml (group 2), and 107 ± 78 pg/ml (group 3) (p = 0.004). Maximum microvascular vasodilatation (percentage increase over baseline) in response to acetylcholine was reduced in group 2 (93% ± 43%) compared with group 1 (187% ± 63%) and group 3 (142% ± 56%) (p = 0.001). The response to sodium nitroprusside also was diminished in group 2 (73% ± 27%) compared with group 1 (126% ± 45%) and group 3 (100% ± 32%) (p = 0.02). Within group 1 the acetylcholine response was higher during the midcycle phase (186% ± 31%) compared with the menstrual phase (147% ± 57%) (p < 0.05). The sodium nitroprusside response also was higher during the midcycle phase (144% ± 31%) compared with the menstrual phase (94% ± 41%) (p < 0.05) Conclusion: The results indicate that estrogens might enhance endothelium-dependent and endothelium-independent vasodilatation in the microcirculation of women.
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页码:1147 / 1147
页数:1
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共 28 条
  • [1] POSTMENOPAUSAL ESTROGEN USE AND HEART-DISEASE RISK-FACTORS IN THE 1980S - RANCHO-BERNARDO, CALIF, REVISITED
    BARRETTCONNOR, E
    WINGARD, DL
    CRIQUI, MH
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1989, 261 (14): : 2095 - 2100
  • [2] ESTROGEN USE AND ALL-CAUSE MORTALITY - PRELIMINARY-RESULTS FROM THE LIPID RESEARCH CLINICS PROGRAM FOLLOW-UP-STUDY
    BUSH, TL
    COWAN, LD
    BARRETTCONNOR, E
    CRIQUI, MH
    KARON, JM
    WALLACE, RB
    TYROLER, HA
    RIFKIND, BM
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1983, 249 (07): : 903 - 906
  • [3] *CDC, 1986, MMWR-MORBID MORTAL W, V35, P653
  • [4] ESTROGEN-BINDING SITES IN ENDOTHELIAL CELL-CULTURES
    COLBURN, P
    BUONASSISI, V
    [J]. SCIENCE, 1978, 201 (4358) : 817 - 819
  • [5] POSTMENOPAUSAL ESTROGEN USE AND MORTALITY - RESULTS FROM A PROSPECTIVE-STUDY IN A DEFINED, HOMOGENEOUS COMMUNITY
    CRIQUI, MH
    SUAREZ, L
    BARRETTCONNOR, E
    MCPHILLIPS, J
    WINGARD, DL
    GARLAND, C
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1988, 128 (03) : 606 - 614
  • [6] ACUTE VASCULAR EFFECTS OF ESTROGEN IN POSTMENOPAUSAL WOMEN
    GILLIGAN, DM
    BADAR, DM
    PANZA, JA
    QUYYUMI, AA
    CANNON, RO
    [J]. CIRCULATION, 1994, 90 (02) : 786 - 791
  • [7] GISCLARD V, 1988, J PHARMACOL EXP THER, V244, P19
  • [8] MODULATION OF ENDOTHELIUM-DEPENDENT FLOW-MEDIATED DILATATION OF THE BRACHIAL-ARTERY BY SEX AND MENSTRUAL-CYCLE
    HASHIMOTO, M
    AKISHITA, M
    ETO, M
    ISHIKAWA, M
    KOZAKI, K
    TOBA, K
    SAGARA, Y
    TAKETANI, Y
    ORIMO, H
    OUCHI, Y
    [J]. CIRCULATION, 1995, 92 (12) : 3431 - 3435
  • [9] CANINE VASCULAR TISSUES ARE TARGETS FOR ANDROGENS, ESTROGENS, PROGESTINS, AND GLUCOCORTICOIDS
    HORWITZ, KB
    HORWITZ, LD
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1982, 69 (04) : 750 - 758
  • [10] ACUTE EFFECT OF 17-BETA-ESTRADIOL ON RABBIT CORONARY-ARTERY CONTRACTILE RESPONSES TO ENDOTHELIN-1
    JIANG, CW
    SARREL, PM
    POOLEWILSON, PA
    COLLINS, P
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (01): : H271 - H275