Specific binding of 2-amino-1,8-naphthyridine into a single guanine bulge as evidenced by photooxidation of GG doublet

被引：15

作者：

Nakatani, K ^{[1
]}

Sando, S ^{[1
]}

Yoshida, K ^{[1
]}

Saito, I ^{[1
]}

机构：

[1] Kyoto Univ, CREST, Fac Engn, Dept Synthet Chem & Biol Chem, Kyoto 6068501, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(00)00667-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Photoirradiation of 2-amino-1,8-naphthyridines in the presence of duplex DNA containing the GG doublet opposite a single bulge was examined. After hot piperidine treatment. DNA cleavage was observed preferentially at the GG opposite a single bulge. The cleavage efficiency was highly dependent on the nature of bulged base. The G cleavage at the GG opposite a single G bulge was exceptionally weak, suggesting an intercalative binding of 2-amino-1,8-naphthyridine chromophore into the GG step. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：335 / 337

页数：3

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