Tackling an essential problem in functional proteomics of Saccharomyces cerevisiae -: art. no. 230

被引：6

作者：

Aparicio, OM ^{[1
]}

机构：

[1] Univ So Calif, Dept Biol Sci, Mol & Computat Biol Program, Los Angeles, CA 90089 USA

来源：

GENOME BIOLOGY | 2003年 / 4卷 / 10期

关键词：

D O I：

10.1186/gb-2003-4-10-230

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Gene inactivation is the cornerstone of functional genetic analysis, but the analysis of essential genes requires conditional inactivation of the gene product. A new study has adapted a simple method for creating conditional alleles to allow large-scale analysis of essential genes in Saccharomyces cerevisiae and has identified a role in DNA replication for a newly identified protein complex.

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