The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp.

被引：236

作者：

Hughes, Chambers C. ^{[1
]}

Prieto-Davo, Alejandra ^{[1
]}

Jensen, Paul R. ^{[1
]}

Fenical, William ^{[1
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 04期

关键词：

D O I：

10.1021/ol702952n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cultivation of an obligate marine Streptomyces strain has furnished the marinopyrroles A and B, densely halogenated, axially chiral metabolites that contain an uncommon bispyrrole structure. X-ray analysis of marinopyrrole B showed that the natural product exists as an atropoenantiomer with the M-configuration. Though configurationally stable at room temperature, M(-)-marinopyrrole A can be racemized at elevated temperatures to yield the non-natural P-(+)-atropo-enantiomer. The marinopyrroles possess potent antibiotic activities against methicillin-resistant Staphylococcus aureus.

引用

页码：629 / 631

页数：3

共 18 条

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