Cytokine gene polymorphisms in acquired bone marrow failure

被引：32

作者：

Gidvani, Vinod

Ramkissoon, Shakti

Sloand, Elaine M.

Young, Neal S.

机构：

[1] NHLBI, Hematol Branch, Div Intramural Res, Bethesda, MD 20892 USA

[2] Wilford Hall USAF Med Ctr, Lackland AFB, TX 78236 USA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2007年 / 82卷 / 08期

关键词：

D O I：

10.1002/ajh.20881

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Some acquired aplastic anemia (AA) results from immune-mediated destruction of hematopoietic stem cells. Cytokine gene polymorphisms are implicated in controlling cytokine production and increasing the susceptibility to some autoimmune diseases. We characterized the IL-6/-174, TNF-alpha/-308, IL-10/-1082, IFN-gamma/+874, TGF beta 1/-509 single nucleotide polymorphisms (SNP's) and the IL1-RA second intron variable number tandem repeat (VNTR) alleles in 73 patients with AA and compared the frequency of genotypes to established control populations. We found that some patients with acquired AA have polymorphisms which are linked to high production of proinflammatory cytokines, particularly TNF-alpha and IFN-gamma.

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页码：721 / 724

页数：4

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