Distribution of opioid peptide gene expression in the limbic system of Fawn-Hooded (alcohol-preferring) and Wistar-Kyoto (alcohol-non-preferring) rats

被引：18

作者：

Cowen, MS ^{[1
]}

Rezvani, A

Jarrott, B

Lawrence, AJ

机构：

[1] Monash Univ, Dept Pharmacol, Clayton, Vic 3168, Australia

[2] Univ N Carolina, Sch Med, Skipper Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA

来源：

BRAIN RESEARCH | 1998年 / 796卷 / 1-2期

关键词：

in situ hybridisation histochemistry; reinforcement; preprodynorphin; preproenkephalin;

D O I：

10.1016/S0006-8993(98)00432-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Preprodynorphin and preproenkephalin mRNA expression was examined in the CNS of two rat strains, the alcohol-preferring Fawn-Hooded (FH) and the alcohol-non-preferring Wistar-Kyoto (WKY), using in situ hybridisation histochemistry. Relative to the WKY, the FH showed significantly lower levels of preproenkephalin mRNA in the striatum and nucleus accumbens (-24% and -17% respectively), but a higher level of preprodynorphin mRNA in the hippocampus (+33%). The depressed level of preproenkephalin mRNA in the nucleus accumbens may be implicated in alcohol-seeking behaviour. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：323 / 326

页数：4

共 19 条

[1] ETHANOL ACCEPTANCE AS A FUNCTION OF GENOTYPE AMOUNTS OF BRAIN [MET]ENKEPHALIN [J].

BLUM, K ;

ELSTON, SFA ;

DELALLO, L ;

BRIGGS, AH ;

WALLACE, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (21) :6510-6512

[2] Distribution of GABAA receptors in the limbic system of alcohol-preferring and non-preferring rats:: in situ hybridisation histochemistry and receptor autoradiography [J].

Chen, F ;

Rezvani, A ;

Jarrott, B ;

Lawrence, AJ .

NEUROCHEMISTRY INTERNATIONAL, 1998, 32 (02) :143-151

[3]

DAVIS VE, 1970, SCIENCE, V167, P1005

[4]

Froehlich J C, 1987, Alcohol Alcohol Suppl, V1, P333

[5] ENDOGENOUS OPIOIDS ARE INVOLVED IN THE GENETICALLY-DETERMINED HIGH PREFERENCE FOR ETHANOL-CONSUMPTION [J].

GEORGE, SR ;

ROLDAN, L ;

LUI, A ;

NARANJO, CA .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1991, 15 (04) :668-672

[6] SUPPRESSION OF ETHANOL INTAKE IN ALCOHOL-PREFERRING RATS BY PRIOR VOLUNTARY SACCHARIN CONSUMPTION [J].

KAMPOVPOLEVOY, AB ;

OVERSTREET, DH ;

REZVANI, AH ;

JANOWSKY, DS .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1995, 52 (01) :59-64

[7] KAPPA(1) RECEPTOR MESSENGER-RNA DISTRIBUTION IN THE RAT CNS - COMPARISON TO KAPPA-RECEPTOR-BINDING AND PRODYNORPHIN MESSENGER-RNA [J].

MANSOUR, A ;

FOX, CA ;

MENG, F ;

AKIL, H ;

WATSON, SJ .

MOLECULAR AND CELLULAR NEUROSCIENCE, 1994, 5 (02) :124-144

[8] Neuropeptide Y gene expression and receptor autoradiography in hypertensive and normotensive rat brain [J].

McLean, KJ ;

Jarrott, B ;

Lawrence, AJ .

MOLECULAR BRAIN RESEARCH, 1996, 35 (1-2) :249-259

[9]

Mogenson GJ., 1993, LIMBIC MOTOR CIRCUIT

[10] LOCALIZATION OF PRODYNORPHIN MESSENGER-RNA IN RAT-BRAIN BY INSITU HYBRIDIZATION USING A SYNTHETIC OLIGONUCLEOTIDE PROBE [J].

MORRIS, BJ ;

HAARMANN, I ;

KEMPTER, B ;

HOLLT, V ;

HERZ, A .

NEUROSCIENCE LETTERS, 1986, 69 (01) :104-108

← 1 2 →