The effect of age on the response of the rat brains to continuous β-amyloid infusion

被引：16

作者：

Nag, S ^{[1
]}

Tang, F ^{[1
]}

机构：

[1] Univ Hong Kong, Fac Med, Dept Physiol, Hong Kong, Hong Kong, Peoples R China

来源：

BRAIN RESEARCH | 2001年 / 889卷 / 1-2期

关键词：

beta-amyloid; aging; memory; choline acetyltransferase; somatostatin;

D O I：

10.1016/S0006-8993(00)03172-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Young (3 months old) and aging (18-21 months old) rats were Infused intracerebroventricularly with beta -amyloid (1-40; 4.2 nmol) for 14 days. In both age groups, beta -amyloid led to deficits in water-maze and decreased choline acetyltransferase activity and somatostatin levels. Cortical substance P levels also decreased whereas neuropeptide Y levels remained unaltered. There were no significant age dependent differences among these neurochemicals except a decrease in hippocampal neuropeptide Y levels in the aging group. It is concluded that young and aging rat brains respond similarly to beta -amyloid infusion. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：303 / 307

页数：5

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