Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches

被引：353

作者：

Bin Emran, Talha ^{[1
,2
]}

Shahriar, Asif ^{[3
]}

Mahmud, Aar Rafi ^{[4
]}

Rahman, Tanjilur ^{[5
]}

Abir, Mehedy Hasan ^{[6
]}

Siddiquee, Mohd. Faijanur-Rob ^{[7
]}

Ahmed, Hossain ^{[8
]}

Rahman, Nova ^{[9
]}

Nainu, Firzan ^{[10
]}

Wahyudin, Elly ^{[10
]}

Mitra, Saikat ^{[11
]}

Dhama, Kuldeep ^{[12
]}

Habiballah, Mahmoud M. ^{[13
,14
]}

Haque, Shafiul ^{[15
,16
]}

Islam, Ariful ^{[17
]}

Hassan, Mohammad Mahmudul ^{[18
,19
]}

机构：

[1] BGC Trust Univ Bangladesh, Dept Pharm, Chittagong, Bangladesh

[2] Daffodil Int Univ, Fac Allied Hlth Sci, Dept Pharm, Dhaka, Bangladesh

[3] Univ Texas Rio Grande Valley, Sch Med, Dept Immunol & Microbiol, Mcallen, TX USA

[4] Mawlana Bhashani Sci & Technol Univ, Dept Biochem & Mol Biol, Tangail, Bangladesh

[5] Univ Chittagong, Fac Biol Sci, Dept Biochem & Mol Biol, Chittagong, Bangladesh

[6] Chattogram Vet & Anim Sci Univ, Fac Food Sci & Technol, Chattogram, Bangladesh

[7] Univ Dhaka, Dept Biochem & Mol Biol, Dhaka, Bangladesh

[8] Univ Dev Alternat, Dept Biotechnol & Genet Engn, Dhaka, Bangladesh

[9] Jahangirnagar Univ, Dept Biochem & Mol Biol, Dhaka, Bangladesh

[10] Hasanuddin Univ, Fac Pharm, Dept Pharm, Makassar, Indonesia

[11] Univ Dhaka, Fac Pharm, Dept Pharm, Dhaka, Bangladesh

[12] ICAR Indian Vet Res Inst, Div Pathol, Bareilly, India

[13] Jazan Univ, Med Lab Technol Dept, Jazan, Saudi Arabia

[14] Jazan Univ, SMIRES Consultat Specialized Med Labs, Jazan, Saudi Arabia

[15] Jazan Univ, Coll Nursing & Allied Hlth Sci, Res & Sci Studies Unit, Jazan, Saudi Arabia

[16] Bursa Uludag Univ, Fac Med, Bursa, Turkey

[17] EcoHlth Alliance, New York, NY USA

[18] Univ Queensland, Sch Vet Sci, Queensland Alliance One Hlth Sci, Gatton, Qld, Australia

[19] Chattogram Vet & Anim Sci Univ, Fac Vet Med, Dept Physiol Biochem & Pharmacol, Chattogram, Bangladesh

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

关键词：

multidrug resistance; cancer; immuno-prevention; microRNA; intracellular and extracellular ATP; EPIDERMAL-GROWTH-FACTOR; CELL LUNG-CANCER; TRANSCRIPTIONAL DOWN-REGULATION; HEPATOCELLULAR-CARCINOMA CELLS; TERMINAL PROLIFERATION ARREST; PREMALIGNANT ORAL LESIONS; GLUTATHIONE-S-TRANSFERASE; OVERCOME DRUG-RESISTANCE; CYTOTOXIC T-LYMPHOCYTES; TUMOR-NECROSIS-FACTOR;

D O I：

10.3389/fonc.2022.891652

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to effective therapeutic interventions against cancer. This review describes the known MDR mechanisms in cancer cells and discusses ongoing laboratory approaches and novel therapeutic strategies that aim to inhibit, circumvent, or reverse MDR development in various cancer types. In this review, we discuss both intrinsic and acquired drug resistance, in addition to highlighting hypoxia- and autophagy-mediated drug resistance mechanisms. Several factors, including individual genetic differences, such as mutations, altered epigenetics, enhanced drug efflux, cell death inhibition, and various other molecular and cellular mechanisms, are responsible for the development of resistance against anticancer agents. Drug resistance can also depend on cellular autophagic and hypoxic status. The expression of drug-resistant genes and the regulatory mechanisms that determine drug resistance are also discussed. Methods to circumvent MDR, including immunoprevention, the use of microparticles and nanomedicine might result in better strategies for fighting cancer.

引用

页数：38

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