Reduced susceptibility of electroporated tumor cell lines to killing by cytotoxic lymphocytes

被引：4

作者：

Dressel, R

Baraki, H

Langer, F

Günther, E

机构：

[1] Univ Gottingen, Immunogenet Abt, Div Immunogenet, D-37073 Gottingen, Germany

[2] Univ Gottingen, Div Med Stat, D-37073 Gottingen, Germany

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 250卷 / 02期

关键词：

D O I：

10.1006/bbrc.1998.9302

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Electroporation is a widely applied method for gene or protein transfer into cells, and it is also used for electrochemotherapy of cancer. During gene transfection studies, electroporation was found to decrease transiently susceptibility of some tumor cell Lines to alloreactive cytotoxic T lymphocytes (CTL) or lymphokine-activated killer (LAI) cells. In each cell line electroporation induced c-fos mRNA In K562 cells HSP70 mRNA induction also occurred. Expression of Grp78, Bcl-2, CD95/Fas, or major histocompatibility complex class I molecules was not affected by electroporation. (C) 1998 Academic Press.

引用

页码：259 / 263

页数：5

共 28 条

[1] Transcriptional modulation of viral reporter gene constructs following induction of the cellular stress response [J].