Role of the immune system in chronic pain

被引：863

作者：

Marchand, F

Perretti, M

McMahon, SB

机构：

[1] Kings Coll London, Wolfson Wing, Neurorestorat Grp, London SE1 1UL, England

[2] Kings Coll London, Wolfson Wing, London Pain Consortium, London SE1 1UL, England

[3] Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, London EC1M 6BQ, England

来源：

NATURE REVIEWS NEUROSCIENCE | 2005年 / 6卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nrn1700

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

During the past two decades, an important focus of pain research has been the study of chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity - spontaneous pain and hyperalgesia - that is associated with these states. For some time it has been recognized that inflammatory mediators released from immune cells can contribute to these persistent pain states. However, it has only recently become clear that immune cell products might have a crucial role not just in inflammatory pain, but also in neuropathic pain caused by damage to peripheral nerves or to the CNS.

引用

页码：521 / 532

页数：12

共 154 条

[51] Macrophage and lymphocyte invasion of dorsal root ganglia after peripheral nerve lesions in the rat [J].