Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture

被引：130

作者：

Shao, Y

Ho, CT ^{[1
]}

Chin, CK

Badmaev, V

Ma, W

Huang, MT

机构：

[1] Rutgers State Univ, Cook Coll, Dept Food Sci, New Brunswick, NJ 08903 USA

[2] Rutgers State Univ, Cook Coll, Dept Plant Sci, New Brunswick, NJ 08903 USA

[3] Sabinsa Corp, Piscataway, NJ USA

[4] Rutgers State Univ, Coll Pharm, Canc Res Lab, Dept Biol Chem, Piscataway, NJ 08855 USA

来源：

PLANTA MEDICA | 1998年 / 64卷 / 04期

关键词：

Boswellia serrata; Burseraceae; boswellic acids; triterpene acids; antileukemia; macromolecule synthesis; cellular growth;

D O I：

10.1055/s-2006-957444

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four major triterpene acids including beta-boswellic acid (1), 3-O-acetyl-beta-boswellic acid (2), 11-keto-beta-boswellic acid (3), and 3-O-acetyl-11-keto-beta-boswellic acid (4) were isolated from the gum resin of Boswellia serrata and examined for their in vitro antitumor activity. They inhibited the synthesis of DNA, RNA and protein in human leukemia HL-60 cells in a dose dependent manner with IC50 values ranging from 0.6 to 7.1 mu M. Among them, compound 4 induced the most pronounced inhibitory effects on DNA, RNA and protein synthesis with IC50 values of 0.6, 0.5, and 4.1 mu M, respectively. The effect of 4 on DNA synthesis was found to be irreversible. Compound 4 significantly inhibited the cellular growth of HL-60 cells, but did not affect cell viability.

引用

页码：328 / 331

页数：4

共 26 条

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