The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position

被引：44

作者：

Levin, JI

Du, MT

DiJoseph, JF

Killar, LM

Sung, A

Walter, T

Sharr, MA

Roth, CE

Moy, FJ

Powers, R

Jin, GX

Cowling, R

Skotnicki, JS

机构：

[1] Wyeth Ayerst Res, Pearl River, NY 10965 USA

[2] Wyeth Ayerst Res, Princeton, NJ 08543 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(00)00642-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, and MMP-13 was prepared and evaluated both in vitro and in vivo. The most potent compound, 6e, has in vivo activity in a rat sponge-wrapped cartilage model. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：235 / 238

页数：4

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