LC-NMR-MS in drug discovery

被引：147

作者：

Corcoran, O

Spraul, M

机构：

[1] Dept Pharm, London SE1 9NN, England

[2] Bruker BioSpin GmbH, D-76287 Rheinstetten, Germany

来源：

DRUG DISCOVERY TODAY | 2003年 / 8卷 / 14期

关键词：

D O I：

10.1016/S1359-6446(03)02749-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nuclear magnetic resonance spectroscopy (NMR) is arguably the most versatile analytical platform for complex mixture analysis. Specifically, interfacing liquid chromatography with parallel NMR and mass spectrometry (LC-NMR-MS) gives comprehensive structural data on metabolites of novel drugs in development. Applications in natural product, combinatorial chemistry and drug metabolism studies are reviewed. Microcoil probes and capillary separation methods have enormous potential. Recent innovations to improve NMR detection limits include CryoFlowProbeS(TM) and on-line solid-phase extraction (LC-SPE-NMR). These state-of-the-art analytical platforms are widely applicable to identifying novel candidate drugs from diverse complex mixtures within a drug discovery strategy.

引用

收藏

页码：624 / 631

页数：8

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