Minimizing analyte electrolysis in an electrospray emitter

被引：44

作者：

Kertesz, V ^{[1
]}

Van Berkel, GJ ^{[1
]}

机构：

[1] Oak Ridge Natl Lab, Div Chem & Analyt Sci, Oak Ridge, TN 37381 USA

来源：

JOURNAL OF MASS SPECTROMETRY | 2001年 / 36卷 / 02期

关键词：

electrospray mass spectrometry; electrolysis; oxidation; stainless-steel emitter; platinum emitter; fused-silica emitter;

D O I：

10.1002/jms.122

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The electrospray (ES) ion source is a controlled-current electrolytic now cell. Electrolytic reactions in the ES emitter capillary are continually ongoing to sustain the production of charged droplets and ultimately gas-phase ions from this device. Under certain circumstances, the analytes under study may be directly involved in these electrolytic processes. It is demonstrated that a simple means to minimize analyte electrolysis is to exchange the normal metal emitter capillary of commercial ES sources with one made of fused silica. This change is shown to provide an ES mass spectrometric system of similar performance in terms of gas-phase ion signal generated for non-electroactive analytes and also assures minimal oxidation of electroactive analytes even at low (2.0 mul min(-1)) solution flow-rates and high (millimolar) solution electrolyte concentrations.

引用

页码：204 / 210

页数：7

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