DNMT3A mutations in acute myeloid leukemia

被引：45

作者：

Shah, Mrinal Y. ^{[1
]}

Licht, Jonathan D. ^{[1
]}

机构：

[1] Northwestern Univ, Div Hematol & Oncol, Chicago, IL 60611 USA

来源：

NATURE GENETICS | 2011年 / 43卷 / 04期

关键词：

DNA METHYLTRANSFERASE; HEMATOPOIETIC STEM; DIFFERENTIATION; CELLS; HYPERMETHYLATION; 5-METHYLCYTOSINE; METHYLATION; TET2;

D O I：

10.1038/ng0411-289

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutant DNMT3A, epigenetic changes and pathogenesis remains to be established.

引用

页码：289 / 290

页数：3

共 15 条

[11] De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells [J].

Tadokoro, Yuko ;

Ema, Hideo ;

Okano, Masaki ;

Li, En ;

Nakauchi, Hiromitsu .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (04) :715-722

[12] Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1 [J].

Tahiliani, Mamta ;

Koh, Kian Peng ;

Shen, Yinghua ;

Pastor, William A. ;

Bandukwala, Hozefa ;

Brudno, Yevgeny ;

Agarwal, Suneet ;

Iyer, Lakshminarayan M. ;

Liu, David R. ;

Aravind, L. ;

Rao, Anjana .

SCIENCE, 2009, 324 (5929) :930-935

[13] DNA Methyltransferase 1 Is Essential for and Uniquely Regulates Hematopoietic Stem and Progenitor Cells [J].

Trowbridge, Jennifer J. ;

Snow, Jonathan W. ;

Kim, Jonghwan ;

Orkin, Stuart H. .

CELL STEM CELL, 2009, 5 (04) :442-449

[14] Array-based genomic resequencing of human leukemia [J].

Yamashita, Y. ;

Yuan, J. ;

Suetake, I. ;

Suzuki, H. ;

Ishikawa, Y. ;

Choi, Y. L. ;

Ueno, T. ;

Soda, M. ;

Hamada, T. ;

Haruta, H. ;

Takada, S. ;

Miyazaki, Y. ;

Kiyoi, H. ;

Ito, E. ;

Naoe, T. ;

Tomonaga, M. ;

Toyota, M. ;

Tajima, S. ;

Iwama, A. ;

Mano, H. .

ONCOGENE, 2010, 29 (25) :3723-3731

[15] Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia [J].

Yan, Xiao-Jing ;

Xu, Jie ;

Gu, Zhao-Hui ;

Pan, Chun-Ming ;

Lu, Gang ;

Shen, Yang ;

Shi, Jing-Yi ;

Zhu, Yong-Mei ;

Tang, Lin ;

Zhang, Xiao-Wei ;

Liang, Wen-Xue ;

Mi, Jian-Qing ;

Song, Huai-Dong ;

Li, Ke-Qin ;

Chen, Zhu ;

Chen, Sai-Juan .

NATURE GENETICS, 2011, 43 (04) :309-U51

← 1 2 →