Apoptosis: Getting rid of the bodies

被引:69
作者
Fadok, VA [1 ]
Henson, PM [1 ]
机构
[1] Natl Jewish Med & Res Ctr, Dept Pediat, Denver, CO 80206 USA
关键词
D O I
10.1016/S0960-9822(98)70438-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cells that die by apoptosis need to be removed before lysis to preserve tissue integrity and function. Recent studies have identified components of the uptake machinery used by phagocytes, but much remains to be learnt, particularly about the recognition mechanisms and their coupling to the uptake machinery.
引用
收藏
页码:R693 / R695
页数:3
相关论文
共 11 条
  • [1] Human CD14 mediates recognition and phagocytosis of apoptotic cells
    Devitt, A
    Moffatt, OD
    Raykundalia, C
    Capra, JD
    Simmons, DL
    Gregory, CD
    [J]. NATURE, 1998, 392 (6675) : 505 - 509
  • [2] THE CLEARANCE OF APOPTOTIC CELLS IN THE LIVER IS MEDIATED BY THE ASIALOGLYCOPROTEIN RECEPTOR
    DINI, L
    AUTUORI, F
    LENTINI, A
    OLIVERIO, S
    PIACENTINI, M
    [J]. FEBS LETTERS, 1992, 296 (02) : 174 - 178
  • [3] FACOK VA, 1998, IN PRESS J IMMUNOL
  • [4] FADOK VA, 1992, J IMMUNOL, V148, P2207
  • [5] Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF
    Fadok, VA
    Bratton, DL
    Konowal, A
    Freed, PW
    Westcott, JY
    Henson, PM
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (04) : 890 - 898
  • [6] Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C-elegans
    Liu, QA
    Hengartner, MO
    [J]. CELL, 1998, 93 (06) : 961 - 972
  • [7] The ATP binding cassette transporter ABC1, is required for the engulfment of corpses generated by apoptotic cell death
    Luciani, MF
    Chimini, G
    [J]. EMBO JOURNAL, 1996, 15 (02) : 226 - 235
  • [8] Multiple systems for recognition of apoptotic lymphocytes by macrophages
    Pradhan, D
    Krahling, S
    Williamson, P
    Schlegel, RA
    [J]. MOLECULAR BIOLOGY OF THE CELL, 1997, 8 (05) : 767 - 778
  • [9] Apoptosis - Phagocytic docking without shocking
    Savill, J
    [J]. NATURE, 1998, 392 (6675) : 442 - 443
  • [10] C-elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
    Wu, YC
    Horvitz, HR
    [J]. NATURE, 1998, 392 (6675) : 501 - 504