Double diastereocontrol in the synthesis of enantiomerically pure polyoxamic acid

被引：36

作者：

Harwood, LM ^{[1
]}

Robertson, SM ^{[1
]}

机构：

[1] Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 23期

关键词：

D O I：

10.1039/a807471b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polyoxamic acid 4 is prepared by a short and efficient process involving diastereochemically matched cycloaddition of 5-(S)-phenylmorpholin-2-one 1 with (S)-glyceraldehyde acetonide 2, followed by sequential hydrolysis and hydrogenolysis of the adduct.

引用

页码：2641 / 2642

页数：2

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