High impulsivity predicts the switch to compulsive cocaine-taking

被引：712

作者：

Belin, David ^{[1
,2
]}

Mar, Adam C. ^{[1
,2
]}

Dalley, Jeffrey W. ^{[1
,2
,3
]}

Robbins, Trevor W. ^{[1
,2
]}

Everitt, Barry J. ^{[1
,2
]}

机构：

[1] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England

[2] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England

[3] Univ Cambridge, Addenbrookes Hosp, Dept Psychiat, Cambridge CB2 2QQ, England

来源：

SCIENCE | 2008年 / 320卷 / 5881期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1126/science.1158136

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Both impulsivity and novelty- seeking have been suggested to be behavioral markers of the propensity to take addictive drugs. However, their relevance for the vulnerability to compulsively seek and take drugs, which is a hallmark feature of addiction, is unknown. We report here that, whereas high reactivity to novelty predicts the propensity to initiate cocaine self- administration, high impulsivity predicts the development of addiction- like behavior in rats, including persistent or compulsive drug- taking in the face of aversive outcomes. This study shows experimental evidence that a shift from impulsivity to compulsivity occurs during the development of addictive behavior, which provides insights into the genesis and neural mechanisms of drug addiction.

引用

页码：1352 / 1355

页数：4

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