Changes in homocysteine levels during normal pregnancy

被引：176

作者：

Walker, MC

Smith, GN

Perkins, SL

Keely, EJ

Garner, PR

机构：

[1] Univ Ottawa, Dept Obstet & Gynaecol, Ottawa, ON K1N 6N5, Canada

[2] Univ Ottawa, Dept Pathol & Lab Med, Ottawa, ON K1N 6N5, Canada

[3] Univ Ottawa, Dept Med, Ottawa, ON K1N 6N5, Canada

[4] Univ Toronto, Dept Obstet & Gynaecol, Toronto, ON, Canada

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1999年 / 180卷 / 03期

关键词：

homocysteine; medical complications of pregnancy; thrombophilia; folic acid; albumin; vitamin B-12;

D O I：

10.1016/S0002-9378(99)70269-3

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: The objective of this study was to determine the changes in total plasma homocysteine concentration that occur during normal pregnancy. STUDY DESIGN: in this cross-sectional study homocysteine was measured in 155 normal women in the first. second, and third trimesters and in nonpregnant controls. In addition, albumin, serum B-12 serum folate, and red blood cell folate concentrations were measured and correlated to homocysteine values. RESULTS: The mean homocysteine concentration (in micromoles per liter) was 5.6 (95% confidence interval 3.9-7.3) at 8-16 weeks' gestation, 4.3 (95% confidence interval 3.5-5.3) at 20-28 weeks' gestation, 5.5 (95% confidence interval 3.3-7.5) at 36-42 weeks' gestation, and 7.9 (95% confidence interval 6.2-9.6) in the non pregnant control group. Homocysteine was significantly lower in all 3 trimesters of pregnancy compared with nonpregnant controls (P < .001). Homocysteine levels were directly correlated with albumin levels, which decreased during pregnancy. Homocysteine concentrations were decreased in subjects taking folic acid supplementation. CONCLUSION: Serum concentrations of homocysteine decrease during pregnancy. This occurs in association with the physiologic fall in albumin during pregnancy, as well as with folio acid supplementation.

引用

页码：660 / 664

页数：5

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