Interferon-γ in healthy subjects:: selective modulation of inflammatory mediators

被引:13
作者
de Metz, J
Hack, CE
Romijn, JA
Levi, M
Out, TA
ten Berge, IJM
Sauerwein, HP
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Internal Med, Div Internal Med, NL-1100 DE Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Dept Endocrinol & Metab, NL-1100 DE Amsterdam, Netherlands
[3] Univ Amsterdam, Acad Med Ctr, Dept Clin Immunol & Rheumatol, NL-1100 DE Amsterdam, Netherlands
[4] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1100 DE Amsterdam, Netherlands
[5] Univ Amsterdam, Acad Med Ctr, Clin & Lab Immunol Unit, NL-1100 DE Amsterdam, Netherlands
[6] Univ Amsterdam, Acad Med Ctr, Expt & Clin Immunol Lab, NL-1100 DE Amsterdam, Netherlands
[7] CLB Blood Supply Fdn, Dept Pathophysiol Plasma Prot, Amsterdam, Netherlands
[8] Leiden Univ, Dept Endocrinol, Med Ctr, NL-2300 RC Leiden, Netherlands
关键词
chemokines; cytokines; interferon-gamma; inflammation; sepsis;
D O I
10.1046/j.1365-2362.2001.00833.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background It is suggested that interferon-gamma (IFN-gamma), like other cytokines, is a mediator in the host inflammatory response, which could be of importance in the pathophysiology of sepsis. The role of IFN-gamma in human host inflammatory responses, however, has not been studied. Design In a placebo-controlled trial we studied the acute effects of IFN-gamma administration on host inflammatory mediators in healthy men: i.e. the cytokine/chemokine cascade system, acute-phase proteins, activation markers of the innate cellular immunity and coagulation/fibrinolysis parameters. Results IFN-gamma increased plasma levels of interleukin-6 (IL-6), IL-8 and IFN-gamma -inducible protein-10 (IP-10) (P < 0.05), but did not affect plasma levels of other cytokines (IL-4, IL-10, tumour necrosis factor-<alpha>, IL-12p40/p70). Plasma concentrations of C-reactive protein and secretory phospholipase A2 both increased (P < 0.05). Plasma levels of the leucocyte activation marker elastase-<alpha>1-antitrypsin complexes increased after IFN-gamma administration (P < 0.05, IFN-<gamma> increased the percentage of high-affinity Fc gamma -receptor (Fc gamma RI) -positive neutrophils (P < 0.05), but did not affect the mean fluorescence intensity of Fc<gamma>RI on neutrophils. Procoagulant and profibrinolytic effects of IFN-gamma were evidenced by increased plasma levels of prothrombin fragment F1+F2, tissue-plasminogen activator and plasmin-alpha2-antiplasmin complexes (P < 0.05). Conclusion We conclude that IFN-<gamma> selectively affects host inflammatory mediators in humans.
引用
收藏
页码:536 / 543
页数:8
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