Antibody cross-reactivity with CD46 and lack of cell surface expression suggest that moesin might not mediate measles virus binding

被引:5
作者
Devaux, P [1 ]
Gerlier, D [1 ]
机构
[1] FAC MED LYON RTH LAENNEC,IVMC,CNRS,UCBL,UMR 5537,F-69372 LYON,FRANCE
关键词
D O I
10.1128/JVI.71.2.1679-1682.1997
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The binding of antimoesin antibodies from ascites fluids to the surfaces of human and rodent cells was found to parallel the level of CD46 expression. No such reactivity was detected with a purified antimoesin antibody which recognized intracellular moesin. In Western blots, antimoesin antibodies were found to react with solubilized CD46 and a recombinant soluble form of CD46. Antimoesin antibodies also reacted with CD46/CD4 molecules containing only the SCR I and II domains required for measles virus (MV) hemagglutinin binding onto CD46. We suggest that the weak cross-reactivity of antimoesin antibodies with CD46 explains the inhibitory effect of these antibodies on MV entry and that moesin is not directly involved in MV binding.
引用
收藏
页码:1679 / 1682
页数:4
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