Microbiology - Tackling anthrax

被引:49
作者
Friedlander, AM [1 ]
机构
[1] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA
关键词
D O I
10.1038/35102660
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Antibiotic development is the first priority in responding to terrorist use of anthrax. But structural studies offer new leads in the hunt for more effective anti-toxin treatments.
引用
收藏
页码:160 / 161
页数:2
相关论文
共 11 条
[1]   Efficacy and safety of recombinant human activated protein C for severe sepsis. [J].
Bernard, GR ;
Vincent, JL ;
Laterre, P ;
LaRosa, SP ;
Dhainaut, JF ;
Lopez-Rodriguez, A ;
Steingrub, JS ;
Garber, GE ;
Helterbrand, JD ;
Ely, EW ;
Fisher, CJ .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (10) :699-709
[2]   Identification of the cellular receptor for anthrax toxin [J].
Bradley, KA ;
Mogridge, J ;
Mourez, M ;
Collier, RJ ;
Young, JAT .
NATURE, 2001, 414 (6860) :225-229
[3]  
LINCOLN R E, 1970, P361
[4]   Designing a polyvalent inhibitor of anthrax toxin [J].
Mourez, M ;
Kane, RS ;
Mogridge, J ;
Metallo, S ;
Deschatelets, P ;
Sellman, BR ;
Whitesides, GM ;
Collier, RJ .
NATURE BIOTECHNOLOGY, 2001, 19 (10) :958-961
[5]   Crystal structure of the anthrax lethal factor [J].
Pannifer, AD ;
Wong, TY ;
Schwarzenbacher, R ;
Renatus, M ;
Petosa, C ;
Bienkowska, J ;
Lacy, DB ;
Collier, RJ ;
Park, S ;
Leppla, SH ;
Hanna, P ;
Liddington, RC .
NATURE, 2001, 414 (6860) :229-233
[6]   Expression of cereolysine AB genes in Bacillus anthracis vaccine strain ensures protection against experimental hemolytic anthrax infection [J].
Pomerantsev, AP ;
Staritsin, NA ;
Mockov, YV ;
Marinin, LI .
VACCINE, 1997, 15 (17-18) :1846-1850
[7]   Dominant-negative mutants of a toxin subunit: An approach to therapy of anthrax [J].
Sellman, BR ;
Mourez, M ;
Collier, RJ .
SCIENCE, 2001, 292 (5517) :695-697
[8]  
SINGER M, 2001, WASHINGTON POST 0924, pA21
[9]   A dominant negative mutant of Bacillus anthracis protective antigen inhibits anthrax toxin action in vivo [J].
Singh, Y ;
Khanna, H ;
Chopra, AP ;
Mehra, V .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (25) :22090-22094
[10]   Kif1C, a kinesin-like motor protein, mediates mouse macrophage resistance to anthrax lethal factor [J].
Watters, JW ;
Dewar, K ;
Lehoczky, J ;
Boyartchuk, V ;
Dietrich, WF .
CURRENT BIOLOGY, 2001, 11 (19) :1503-1511