Neurotrophin-4/5 treatment reduces infarct size in rats with middle cerebral artery occlusion

被引：26

作者：

Chan, KM

Lam, DTN

Pong, K

Widmer, HR

Hefti, F

机构：

[1] UNIV SO CALIF,ETHEL PERCY ANDRUS GERONTOL CTR,LOS ANGELES,CA 90089

[2] UNIV SO CALIF,DEPT BIOL SCI,LOS ANGELES,CA 90089

来源：

NEUROCHEMICAL RESEARCH | 1996年 / 21卷 / 07期

关键词：

neurotrophin; trk receptor; infarct; stroke;

D O I：

10.1007/BF02532298

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this study was to determine whether neurotrophin-4/5 (NT-4/5) treatment alters infarction volume following permanent focal cerebral ischemia in the rat. Permanent focal cerebral ischemia was produced in adult male rats by intraluminal occlusion of the right middle cerebral artery. NT-4/5 was administered intraventricularly one day before and immediately following occlusion. Rats were sacrificed at 1, 4 and 7 days after occlusion. NT-4/5 treatment reduced infarction volume by 34% when compared to control rats 1 day after occlusion. Infarction volume was unaltered by treatment 4 to 7 days after occlusion. Middle cerebral artery occlusion led to a significant reduction in levels of mRNAs coding for catalytic and truncated TrkB receptors. This expression was unaffected by NT-4/5 treatment.

引用

页码：763 / 767

页数：5

共 32 条

[1] THE TRK FAMILY OF NEUROTROPHIN RECEPTORS [J].