Function of liprins in cell motility

被引：21

作者：

de Curtis, Ivan ^{[1
,2
]}

机构：

[1] Ist Sci San Raffaele, Cell Adhes Unit, Div Neurosci, I-20132 Milan, Italy

[2] San Raffaele Univ, I-20132 Milan, Italy

来源：

EXPERIMENTAL CELL RESEARCH | 2011年 / 317卷 / 01期

关键词：

Liprin; Extracellular matrix; Integrins; Cell adhesion; Cell migration; PROTEIN-TYROSINE-PHOSPHATASE; EXPRESSION MICROARRAY ANALYSES; RESOLUTION COPY NUMBER; ACTIVE ZONE; IN-VIVO; NEUROTRANSMITTER RELEASE; INTERACTING PROTEINS; C; ELEGANS; GIT FAMILY; LAR;

D O I：

10.1016/j.yexcr.2010.09.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Liprins have been known for years to play an essential role in setting up functional synapses in the nervous system On the other hand these proteins had been first identified in non-neuronal cells as multivalent proteins that may affect the integrin-mediated interactions of the cells with extracellular matrix ligands Although the research on the function of liprins in non-neuronal cells has been quiescent for several years a number of recent findings are putting them back on stage again as Important players also in the regulation of non-neuronal cell motility and possibly of tumor cell behavior The aim of this review is to highlight the findings supporting the importance of hprins as central regulators of cell adhesion and motility making them an interesting family of proteins to be considered for future studies on the mechanisms regulating cell migration (C) 2010 Elsevier Inc All rights reserved

引用

页码：1 / 8

页数：8

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