Study of N-benzoyl-activation in the HgCl2-promoted guanylation reaction of thioureas.: Synthesis and structural analysis of N-benzoyl-guanidines

被引：64

作者：

Cunha, S

Costa, MB

Napolitano, HB

Lariucci, C

Vencato, I

机构：

[1] Univ Fed Goias, Inst Quim, Lab Bioatividade Mol, BR-74001970 Goiania, Go, Brazil

[2] Univ Fed Goias, Inst Fis, Lab Cristalog & Mat, BR-74001970 Goiania, Go, Brazil

来源：

TETRAHEDRON | 2001年 / 57卷 / 09期

关键词：

guanidines; thioureas; guanylation reaction; X-ray analysis;

D O I：

10.1016/S0040-4020(00)01168-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this work, it is demonstrated that the benzoyl group is an activating group for thioureas in the HgCl2-guanylation reaction. Thus N-benzoyl-thioureas containing electronically neutral and even electron-withdrawing or electron-releasing substituents are converted into guanidines with reasonable yields. In addition, NMR and X-ray structural analyses were performed to understand the intra- and intermolecular features of the synthesized guanidines. (C) 2001 Elsevier Science Ltd. All rights reserved.

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收藏

页码：1671 / 1675

页数：5

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