A desymmetrization route to fused Troger's base analogues:: Synthesis, isolation, and characterization of the first anti-anti diastereomer of a fused tris-Troger's base analogue

被引：31

作者：

Hansson, A ^{[1
]}

Wixe, T ^{[1
]}

Bergquist, KE ^{[1
]}

Wärnmark, K ^{[1
]}

机构：

[1] Lund Univ, Dept Chem, SE-22100 Lund, Sweden

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 10期

关键词：

D O I：

10.1021/ol050513g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A desymmetrization route to fused Troger's base analogues was developed. In this way, the synthesis of the first example of an anti-anti diastereomer of a fused tris-Troger's base analogue was accomplished. The resulting compound 5b is a nonlinear symmetric regioisomer obtained from p-bromoaniline in 7% yield. The corresponding syn-anti diastereomer 5a was obtained in 4% yield.

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页码：2019 / 2022

页数：4

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