Super fast cobalt carbonyl-mediated synthesis of ureas

被引：35

作者：

Enquist, PA ^{[1
]}

Nilsson, P ^{[1
]}

Edin, J ^{[1
]}

Larhed, M ^{[1
]}

机构：

[1] Uppsala Univ, Dept Med Chem, SE-75123 Uppsala, Sweden

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 19期

关键词：

microwave; carbonylation; cobalt carbonyl; urea; isocyanate;

D O I：

10.1016/j.tetlet.2005.03.076

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fast cobalt carbonyl-mediated generation of ureas from primary amines was performed using high-density microwave irradiation. This enhanced method permitted the preparation of symmetrical ureas in good yields and unsymmetrical ureas in moderate yields. The reaction times varied between 10 s and 40 min. The proposed mechanisin for the reaction includes in situ generation of an intermediate isocyanate that subsequently traps the free amine, producing the urea product. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3335 / 3339

页数：5

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