Synthesis of stilbene-fused 2′-hydroxychalcones and flavanones

被引：19

作者：

Akcok, Ismail ^{[1
]}

Cagir, Ali ^{[1
]}

机构：

[1] Izmir Inst Technol, Fac Sci, Dept Chem, TR-35430 Urla Izmir, Turkey

来源：

BIOORGANIC CHEMISTRY | 2010年 / 38卷 / 4-6期

关键词：

Stilbene; Chalcone; Flavanone; Claisen-Schmidt reaction; Michael addition; Heck reaction; BIOLOGICAL EVALUATION; FREE PALLADIUM; CHALCONES; FLAVONOIDS; LIGAND;

D O I：

10.1016/j.bioorg.2010.04.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthesis of stilbene-fused chalcones and flavanones were successfully completed. Molecules were designed in a way to mimic the structural features of both "stilbene and chalcones" or "stilbene and flavanones" at the same time, and synthesized by three steps. Heck reactions of 3-bromobenzaldehyde with styrene derivatives gave corresponding (E)-stilbenes, which were reacted with acetophenones to furnish stilbene-fused 2'-hydroxychalcones under basic conditions. Finally, intramolecular cyclization reactions were performed to produce stilbene-fused flavanones. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：139 / 143

页数：5

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