Hypothetical role of RNA damage avoidance in preventing human disease

被引：44

作者：

Brégeon, D ^{[1
]}

Sarasin, A ^{[1
]}

机构：

[1] Inst Gustave Roussy PR2, CNRS, UPR 2169, F-94805 Villejuif, France

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2005年 / 577卷 / 1-2期

关键词：

RNA lesions; RNA repair; cell death; cancer;

D O I：

10.1016/j.mrfmmm.2005.04.002

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Most of nucleic acids damaging agents are not only restricted to DNA but equally affect DNA and RNA molecules. Considering that RNA damage could be very toxic for the cell, a property used by some cancer treatments, it would not be unexpected to find out that several proteins may be involved in RNA damage avoidance mechanisms helping cells to counteract such cytotoxic effects. Up to now, only one specific repair mechanism allowing cells to deal with toxic effects of methylated RNA have been described. However, there are in the literature several data suggesting that this study may only be the tip of the iceberg and that cells might be able to counteract the deleterious effects of a large variety of RNA damage. In this review, we will discuss the different proteins that may be involved in the mechanism of RNA damage avoidance and their potential role in human diseases. (C) 2005 Elsevier B.V. All rights reserved.

引用

页码：293 / 302

页数：10

共 51 条

[1] Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA [J].

Aas, PA ;

Otterlei, M ;

Falnes, PO ;

Vågbo, CB ;

Skorpen, F ;

Akbari, M ;

Sundheim, O ;

Bjorås, M ;

Slupphaug, G ;

Seeberg, E ;

Krokan, HE .

NATURE, 2003, 421 (6925) :859-863

[2] ENDOGENOUS MUTAGENS AND THE CAUSES OF AGING AND CANCER [J].

AMES, BN ;

GOLD, LS .

MUTATION RESEARCH, 1991, 250 (1-2) :3-16

[3]

Aravind L., 2001, GENOME BIOL, V2

[4] Nonsense-mediated mRNA decay: terminating erroneous gene expression [J].

Baker, KE ;

Parker, R .

CURRENT OPINION IN CELL BIOLOGY, 2004, 16 (03) :293-299

[5] Our genome unveiled [J].

Baltimore, D .

NATURE, 2001, 409 (6822) :814-816

[6] RNA repair: Damage control [J].

Bellacosa, A ;

Moss, EG .

CURRENT BIOLOGY, 2003, 13 (12) :R482-R484

[7] Transcriptional mutagenesis induced by uracil and 8-oxoguanine in Escherichia coli [J].

Brégeon, D ;

Doddridge, ZA ;

You, HJ ;

Weiss, B ;

Doetsch, PW .

MOLECULAR CELL, 2003, 12 (04) :959-970

[8] The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells [J].

Brumbaugh, KM ;

Otterness, DM ;

Geisen, C ;

Oliveira, V ;

Brognard, J ;

Li, XJ ;

Lejeune, F ;

Tibbetts, RS ;

Maquat, LE ;

Abraham, RT .

MOLECULAR CELL, 2004, 14 (05) :585-598

[9] mRNA degradation - a tale of poly(A) and multiprotein machines [J].

Carpousis, AJ ;

Vanzo, NF ;

Raynal, LC .

TRENDS IN GENETICS, 1999, 15 (01) :24-28

[10] THE ESCHERICHIA-COLI ALKB PROTEIN PROTECTS HUMAN-CELLS AGAINST ALKYLATION-INDUCED TOXICITY [J].

CHEN, BRJ ;

CARROLL, P ;

SAMSON, L .

JOURNAL OF BACTERIOLOGY, 1994, 176 (20) :6255-6261

← 1 2 3 4 5 6 →