Channel behavior in a gamma-aminobutyrate transporter

被引：89

作者：

Cammack, JN

Schwartz, EA

机构：

[1] Dept. Pharmacol. Physiological Sci., University of Chicago, Chicago, IL 60637

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1996年 / 93卷 / 02期

关键词：

D O I：

10.1073/pnas.93.2.723

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Current produced by a gamma-aminobutyrate (GABA) transporter stably transfected into a mammalian cell line was observed in cell-attached and excised membrane patches. When GABA was absent, a fraction of the transporters produced cation-permeable channels. When GABA plus Na+ was on either side of the membrane, the majority of transporters produced a high-frequency current noise attributed to the movement of ions In an occluded pore.

引用

页码：723 / 727

页数：5

共 18 条

[1] ORALLY ACTIVE AND POTENT INHIBITORS OF GAMMA-AMINOBUTYRIC ACID UPTAKE
ALI, FE
BONDINELL, WE
DANDRIDGE, PA
FRAZEE, JS
GARVEY, E
GIRARD, GR
KAISER, C
KU, TW
LAFFERTY, JJ
MOONSAMMY, GI
OH, HJ
RUSH, JA
SETLER, PE
STRINGER, OD
VENSLAVSKY, JW
VOLPE, BW
YUNGER, LM
ZIRKLE, CL
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (05) : 653 - 660
[2] COUPLING OF CFTR CL- CHANNEL GATING TO AN ATP HYDROLYSIS CYCLE
BAUKROWITZ, T
HWANG, TC
GADSBY, DC
NAIRN, AC
[J]. NEURON, 1994, 12 (03) : 473 - 482
[3] A GABA TRANSPORTER OPERATES ASYMMETRICALLY AND WITH VARIABLE STOICHIOMETRY
CAMMACK, JN
RAKHILIN, SV
SCHWARTZ, EA
[J]. NEURON, 1994, 13 (04) : 949 - 960
[4] IONS REQUIRED FOR THE ELECTROGENIC TRANSPORT OF GABA BY HORIZONTAL CELLS OF THE CATFISH RETINA
CAMMACK, JN
SCHWARTZ, EA
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1993, 472 : 81 - 102
[5] RELAXATION AND FLUCTUATIONS OF MEMBRANE CURRENTS THAT FLOW THROUGH DRUG-OPERATED CHANNELS
COLQUHOUN, D
HAWKES, AG
[J]. PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1977, 199 (1135): : 231 - 262
[6] ELIASOF S, 1993, J NEUROSCI, V13, P402
[7] EXTRACELLULAR ACCESS TO THE NA,K PUMP - PATHWAY SIMILAR TO ION CHANNEL
GADSBY, DC
RAKOWSKI, RF
DEWEER, P
[J]. SCIENCE, 1993, 260 (5104) : 100 - 103
[8] GUASTELLA J, 1990, SCIENCE, V260, P100
[9] CHANNEL-LIKE FUNCTION OF THE NA,K PUMP PROBED AT MICROSECOND RESOLUTION IN GIANT MEMBRANE PATCHES
HILGEMANN, DW
[J]. SCIENCE, 1994, 263 (5152) : 1429 - 1432
[10] SPECTRAL ANALYSIS OF CURRENT NOISE GENERATED BY CARRIER-MEDIATED ION-TRANSPORT
KOLB, HA
LAUGER, P
[J]. JOURNAL OF MEMBRANE BIOLOGY, 1978, 41 (02) : 167 - 187

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