A new place conditioning paradigm to study tolerance to opiates in mice

被引：3

作者：

Contarino, A

Drago, F

Zanotti, A

Natolino, F

Berti, T

Giusti, P

机构：

[1] Dipartimento Farmacol, I-35131 Padua, Italy

[2] Ist Farmacol, I-95125 Catania, Italy

[3] Fidia Res Labs, I-35031 Abano Terme, Italy

来源：

NEUROREPORT | 1999年 / 10卷 / 03期

关键词：

conditioned place preference; mice; morphine; reward; tolerance;

D O I：

10.1097/00001756-199902250-00014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

TOLERANCE to the rewarding properties of morphine was investigated in mice using a new conditioned place preference (CPP) procedure. Four pairings of morphine with specific environmental cues induced a significant CPP for the drug-paired cues. Further opiate conditioning trials in the presence of the same environmental cues revealed no change in the drug-induced CPP on repeated test sessions. Subsequent exposure of the same animals to conditioning trials by pairing morphine with a set of novel environmental cues showed that the opiate was still able to produce a CPP in mice treated with a total of 16 morphine injections. The present CPP paradigm may prove useful to investigate tolerance to the rewarding properties of drugs of abuse. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：517 / 521

页数：5

共 23 条

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