Highly anti-selective conjugate addition of arylcuprates to a γ-alkoxy-α,β-enoate.: A new method to address stereochemical challenges presented by Amaryllidaceae alkaloids

被引：14

作者：

Manpadi, M ^{[1
]}

Kornienko, A ^{[1
]}

机构：

[1] New Mexico Inst Min & Technol, Dept Chem, Socorro, NM 87801 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 26期

关键词：

acyclic stereoselection; arylcuprate; amaryllidaceae alkaloids;

D O I：

10.1016/j.tetlet.2005.05.006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various substituted arylcuprates undergo stereocontrolled additions to a D-mannitol-derived gamma-alkoxy-alpha, beta-enoate with exclusive anti-selectivity. The method is well suited for the preparation of a broad range of biologically active Amaryllidaceae alkaloids and their aromatic analogues. A model accounting for the stereochemical outcome of this process is presented. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：4433 / 4437

页数：5

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