An efficient synthesis of C-20-C-25 building blocks for calyculin A

被引：25

作者：

Hamada, Y

Yokokawa, F

Kabeya, M

Hatano, K

Kurono, Y

Shioiri, T

机构：

[1] NAGOYA CITY UNIV,FAC PHARMACEUT SCI,MIZUHO KU,NAGOYA,AICHI 467,JAPAN

[2] CHIBA UNIV,FAC PHARMACEUT SCI,INAGE KU,CHIBA 263,JAPAN

[3] KOWA CO LTD,TOKYO RES LABS,HIGASHIMURAYAMA 189,JAPAN

来源：

TETRAHEDRON | 1996年 / 52卷 / 24期

关键词：

D O I：

10.1016/0040-4020(96)00383-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The C-20-C-25 building blocks 2 and 3a for calyculin A, a protein phosphatase inhibitor, have been efficiently prepared from L-malic acid utilizing the Grignard reaction of the Weinreb amides 8 and 14, followed by stereoselective reduction of the ketones 9 and 15, respectively, as the key steps. Copyright (C) 1996 Elsevier Science Ltd

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收藏

页码：8297 / 8306

页数：10

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