Immunoprecipitation of [3H]dihydroartemisinin translationally controlled tumor protein (TCTP) adducts from Plasmodium falciparum-infected erythrocytes by using anti-TCTP antibodies

被引：47

作者：

Bhisutthibhan, J ^{[1
]}

Meshnick, SR ^{[1
]}

机构：

[1] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 08期

关键词：

D O I：

10.1128/AAC.45.8.2397-2399.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Artemisinin and its derivatives are endoperoxide-containing antimalarial drugs that appear to form adducts in situ with the Plasmodium falciparum translationally controlled tumor protein (TCTP) homolog. Immunoprecipitation with antibody to recombinant TCTP suggests that adducts may form with both monomeric and dimeric TCTP.

引用

页码：2397 / 2399

页数：3

共 36 条

[1] Reaction between ferriprotoporphyrin IX and the antimalarial endoperoxide artesunate gives an intermediate species with enhanced redox catalytic activity [J].

Adams, PA ;

Berman, PA .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1996, 48 (02) :183-187

[2]

[Anonymous], 2001, ANTIMALARIAL CHEMOTH

[3]

ASAWAMAHASAKDA W, 1994, J LAB CLIN MED, V123, P757

[4] REACTION OF ANTIMALARIAL ENDOPEROXIDES WITH SPECIFIC PARASITE PROTEINS [J].

ASAWAMAHASAKDA, W ;

ITTARAT, I ;

PU, YM ;

ZIFFER, H ;

MESHNICK, SR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (08) :1854-1858

[5] Structure-activity relationships of the antimalarial agent artemisinin .4. Effect of substitution at C-3 [J].

Avery, MA ;

Mehrotra, S ;

Bonk, JD ;

Vroman, JA ;

Goins, DK ;

Miller, R .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (15) :2900-2906

[6] Synthesis and reactions of antimalarial bicyclic peroxides [J].

Bachi, MD ;

Korshin, EE ;

Hoos, R ;

Szpilman, AM .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2000, 37 (03) :639-646

[7] In-vitro interaction of artemisinin with intact human erythrocytes, erythrocyte ghosts, haemoglobin and carbonic anhydrase [J].

Bakhshi, HB ;

Gordi, T ;

Ashton, M .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1997, 49 (02) :223-226

[8] In vitro and in vivo potentiation of artemisinin and synthetic endoperoxide antimalarial drugs by metalloporphyrins [J].

Benoit-Vical, F ;

Robert, A ;

Meunier, B .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (10) :2836-2841

[9] Artemisinin enhances heme-catalysed oxidation of lipid membranes [J].

Berman, PA ;

Adams, PA .

FREE RADICAL BIOLOGY AND MEDICINE, 1997, 22 (07) :1283-1288

[10] Artemisinin mediated alteration of haemin to a δ-meso oxidation product:: relevance to mechanism of action [J].

Bharel, S ;

Vishwakarma, RA ;

Jain, SK .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1998, (14) :2163-2166

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