Fas (APO-1/CD95) in inflammatory CNS diseases: intrathecal release in bacterial meningitis

被引：9

作者：

Fassbender, K ^{[1
]}

Eschenfelder, C ^{[1
]}

Hennerici, M ^{[1
]}

机构：

[1] Heidelberg Univ, Klinikum Mannheim, Dept Neurol, D-68135 Mannheim, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1999年 / 93卷 / 1-2期

关键词：

Fas; apoptosis; cerebral inflammation;

D O I：

10.1016/S0165-5728(98)00210-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Release of Fas (APO-1, CD95), a type L-membrane protein which plays a crucial role in cytokine-mediated apoptosis was investigated in bacterial meningitis, viral meningoencephalitis and multiple sclerosis in vivo. After correction for bloodbrain-CSF-disruption, significantly increased intrathecal release of Fas was demonstrated exclusively in bacterial meningitis arguing for an apoptotic cell death of granulocytes in the subarachnoidal space aimed to self-limit inflammatory host response. (C) 1999 Elsevier Science B.V. AU rights reserved.

引用

收藏

页码：122 / 125

页数：4

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