Detection of the soluble form of the Fas molecule in patients with multiple sclerosis and human T-lymphotropic virus type I-associated myelopathy

被引:47
作者
Inoue, A
Koh, CS
Sakai, T
Yamazaki, M
Yanagisawa, N
Usuku, K
Osame, M
机构
[1] SHINSHU UNIV,SCH MED,DEPT MED NEUROL,MATSUMOTO,NAGANO 390,JAPAN
[2] KAGOSHIMA UNIV,SCH MED,DEPT INTERNAL MED 3,KAGOSHIMA 890,JAPAN
关键词
Fas; multiple sclerosis; human T-lymphotropic virus type I-associated myelopathy;
D O I
10.1016/S0165-5728(97)00012-X
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We evaluated the presence of soluble Fas molecule (sFas) in the cerebrospinal fluids (CSF) and the sera of patients with multiple sclerosis (MS) or human T-lymphotropic virus type I (HTLV-I) associated myelopathy (HAM) using an enzyme-linked immunosorbent assay (ELISA). Patients with multiple sclerosis in the active phase had higher sFas serum levels than control (p < 0.005). In addition, significantly increased serum levels of sFas were found in patients with HAM (p < 0.005). We found a significantly increased CSF levels of sFas in patients with HAM and patients with MS in the active stage (p < 0.005). These results suggest that serum sFas may be related to clinical activity in patients with MS and that Fas may play an important role in the pathogenesis of HAM.
引用
收藏
页码:141 / 146
页数:6
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