Asymmetric epoxidation of α,β-unsaturated ketones catalyzed by chiral ytterbium complexes

被引：44

作者：

Chen, RF

Qian, CT

de Vries, JG

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

[2] Dsm Res & Patents, Dept LS2CC, NL-6160 MD Geleen, Netherlands

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 39期

关键词：

D O I：

10.1016/S0040-4039(01)01336-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several derivatives of (S)-(-)-BINOL ligands with 6,6 ' -substitutents were synthesized and applied as chiral ligands in the Yb(O-i-Pr)(3)-catalyzed asymmetric epoxidation of alpha,beta -unsaturated ketones. Superior results were obtained with 6,6 ' -diphenyl-BINOL, exemplified in the asymmetric epoxidation of (E)-1,3-diphenylprop-2-en-1-one in 91% yield and up to 97% ee. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：6919 / 6921

页数：3

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