Cancer epigenetics: Modifications, screening, and therapy

被引：193

作者：

Gal-Yam, Einav Nili ^{[1
]}

Saito, Yoshimasa ^{[1
]}

Egger, Gerda ^{[1
]}

Jones, Peter A. ^{[1
]}

机构：

[1] Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Keck Sch Med, Dept Urol Biochem & Mol Biol, Los Angeles, CA 90089 USA

来源：

ANNUAL REVIEW OF MEDICINE | 2008年 / 59卷

关键词：

dNA methylation; historic modification; CpG islands;

D O I：

10.1146/annurev.med.59.061606.095816

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Deregulation of gene expression is a hallmark of cancer. Although genetic lesions have been the focus of cancer research for many years, it has become increasingly recognized that aberrant epigenetic modifications also play major roles in the tumorigenic process. These modifications are imposed on chromatin, do not change the nucleotide sequence of DNA, and are manifested by specific patterns of gene expression that are heritable through many cell divisions. We review these modifications in normal and cancer cells and the evolving approaches used to study them. Additionally, we outline advances in their potential use for cancer diagnostics and targeted epigenetic therapy.

引用

页码：267 / 280

页数：14

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