Cancer epigenetics: Modifications, screening, and therapy

被引：193

作者：

Gal-Yam, Einav Nili ^{[1
]}

Saito, Yoshimasa ^{[1
]}

Egger, Gerda ^{[1
]}

Jones, Peter A. ^{[1
]}

机构：

[1] Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Keck Sch Med, Dept Urol Biochem & Mol Biol, Los Angeles, CA 90089 USA

来源：

ANNUAL REVIEW OF MEDICINE | 2008年 / 59卷

关键词：

dNA methylation; historic modification; CpG islands;

D O I：

10.1146/annurev.med.59.061606.095816

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Deregulation of gene expression is a hallmark of cancer. Although genetic lesions have been the focus of cancer research for many years, it has become increasingly recognized that aberrant epigenetic modifications also play major roles in the tumorigenic process. These modifications are imposed on chromatin, do not change the nucleotide sequence of DNA, and are manifested by specific patterns of gene expression that are heritable through many cell divisions. We review these modifications in normal and cancer cells and the evolving approaches used to study them. Additionally, we outline advances in their potential use for cancer diagnostics and targeted epigenetic therapy.

引用

页码：267 / 280

页数：14

共 83 条

[11] Sensitive and quantitative universal Pyrosequencing™ methylation analysis of CpG sites [J].

Colella, S ;

Shen, L ;

Baggerly, KA ;

Issa, JPJ ;

Krahe, R .

BIOTECHNIQUES, 2003, 35 (01) :146-+

[12] Mapping the cancer genome - Pinpointing the genes involved in cancer will help chart a new course across the complex landscape of human malignancies [J].

Collins, Francis S. ;

Barker, Anna D. .

SCIENTIFIC AMERICAN, 2007, 296 (03) :50-57

[13] FUNCTIONAL STRIATED-MUSCLE CELLS FROM NON-MYOBLAST PRECURSORS FOLLOWING 5-AZACYTIDINE TREATMENT [J].

CONSTANTINIDES, PG ;

JONES, PA ;

GEVERS, W .

NATURE, 1977, 267 (5609) :364-366

[14] Aberrant CpG-island methylation has non-random and tumour-type-specific patterns [J].

Costello, JF ;

Frühwald, MC ;

Smiraglia, DJ ;

Rush, LJ ;

Robertson, GP ;

Gao, X ;

Wright, FA ;

Feramisco, JD ;

Peltomäki, P ;

Lang, JC ;

Schuller, DE ;

Yu, L ;

Bloomfield, CD ;

Caligiuri, MA ;

Yates, A ;

Nishikawa, R ;

Huang, HJS ;

Petrelli, NJ ;

Zhang, XL ;

O'Dorisio, MS ;

Held, WA ;

Cavenee, WK ;

Plass, C .

NATURE GENETICS, 2000, 24 (02) :132-138

[15] The expanding role of epigenetics in the development, diagnosis and treatment of prostate cancer and benign prostatic hyperplasia [J].

Dobosy, Joseph R. ;

Roberts, J. Lea W. ;

Fu, Vivian X. ;

Jarrard, David F. .

JOURNAL OF UROLOGY, 2007, 177 (03) :822-831

[16]

Eads CA, 2000, CANCER RES, V60, P5021

[17] MethyLight: a high-throughput assay to measure DNA methylation [J].

Eads, Cindy A. ;

Danenberg, Kathleen D. ;

Kawakami, Kazuyuki ;

Saltz, Leonard B. ;

Blake, Corey ;

Shibata, Darryl ;

Danenberg, Peter V. ;

Laird, Peter W. .

NUCLEIC ACIDS RESEARCH, 2000, 28 (08) :32

[18] DNA methylation profiling of human chromosomes 6, 20 and 22 [J].

Eckhardt, Florian ;

Lewin, Joern ;

Cortese, Rene ;

Rakyan, Vardhman K. ;

Attwood, John ;

Burger, Matthias ;

Burton, John ;

Cox, Tony V. ;

Davies, Rob ;

Down, Thomas A. ;

Haefliger, Carolina ;

Horton, Roger ;

Howe, Kevin ;

Jackson, David K. ;

Kunde, Jan ;

Koenig, Christoph ;

Liddle, Jennifer ;

Niblett, David ;

Otto, Thomas ;

Pettett, Roger ;

Seemann, Stefanie ;

Thompson, Christian ;

West, Tony ;

Rogers, Jane ;

Olek, Alex ;

Berlin, Kurt ;

Beck, Stephan .

NATURE GENETICS, 2006, 38 (12) :1378-1385

[19] Chromosomal instability and tumors promoted by DNA hypomethylation [J].

Eden, A ;

Gaudet, F ;

Waghmare, A ;

Jaenisch, R .

SCIENCE, 2003, 300 (5618) :455-455

[20] Epigenetics in human disease and prospects for epigenetic therapy [J].

Egger, G ;

Liang, GN ;

Aparicio, A ;

Jones, PA .

NATURE, 2004, 429 (6990) :457-463

← 1 2 3 4 5 6 7 8 9 →