Mesenchymal niches of bone marrow in cancer

被引：14

作者：

Abarrategi, Ander ^{[1
]}

Marinas-Pardo, Luis ^{[1
,2
]}

Mirones, Isabel ^{[1
]}

Rincon, Esther ^{[1
]}

Garcia-Castro, Javier ^{[1
]}

机构：

[1] Inst Salud Carlos III, Unidad Biotecnol Celular, Area Bio Celular & Desarrollo, ES-28220 Madrid, Spain

[2] Complexo Hosp Univ A Coruna, Unidad Invest Resp, Inst Invest Biomed A Coruna INIBIC, La Coruna, Spain

来源：

CLINICAL & TRANSLATIONAL ONCOLOGY | 2011年 / 13卷 / 09期

关键词：

Tumour microenvironment; Mesenchymal stem cells; Bone marrow; Metastasis; Niche; Tumorigenesis; STEM-CELL NICHE; ACUTE LYMPHOBLASTIC-LEUKEMIA; MULTIPLE-MYELOMA; STROMAL CELLS; INTERLEUKIN-6; PRODUCTION; ADHESION MOLECULES; TUMOR STROMA; MICROENVIRONMENT; GROWTH; CXCR4;

D O I：

10.1007/s12094-011-0706-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Over the last decade, genetic and cell biology studies have indicated that tumour growth is not only determined by malignant cancer cells themselves, but also by the tumour microenvironment. Cells present in the tumour microenvironment include fibroblasts, vascular, smooth muscle, adipocytes, immune cells and mesenchymal stem cells (MSC). The nature of the relationship between MSC and tumour cells appears dual and whether MSC are proor anti-tumorigenic is a subject of controversial reports. This review is focused on the role of MSC and bone marrow (BM) niches in cancer.

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收藏

页码：611 / 616

页数：6

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