Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci

被引：17

作者：

HeinzeKrauss, I ^{[1
]}

Angehrn, P ^{[1
]}

Guerry, P ^{[1
]}

Hebeisen, P ^{[1
]}

Hubschwerlen, C ^{[1
]}

Kompis, I ^{[1
]}

Page, MGP ^{[1
]}

Richter, HGF ^{[1
]}

Runtz, V ^{[1
]}

Stalder, H ^{[1
]}

Weiss, U ^{[1
]}

Wei, CC ^{[1
]}

机构：

[1] F HOFFMANN LA ROCHE & CO LTD,NUTLEY,NJ 07110

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 39卷 / 09期

关键词：

D O I：

10.1021/jm950886v

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and structure-activity relationships of a new class of vinylcephalosporins substituted with a lactamyl residue (1) are described. These compounds show excellent activity against enterococci and retain the broad spectrum activity of third-generation cephalosporins such as ceftriaxone.

引用

页码：1864 / 1871

页数：8

共 29 条

[1] AKAGI H, 1994, Patent No. 630899
[2] ANGEHRN P, 1994, Patent No. 620225
[3] ASZODI J, 1993, Patent No. 551034
[4] SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME C-3-LACTONYL SUBSTITUTED CEPHALOSPORINS
BATESON, JH
BURTON, G
FELL, SCM
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (11) : 2219 - 2224
[5] CANEPARI P, 1986, J GEN MICROBIOL, V132, P625
[6] ISOLATION OF A COVALENT INTERMEDIATE IN BETA-LACTAMASE-I CATALYSIS
CARTWRIGHT, SJ
FINK, AL
[J]. FEBS LETTERS, 1982, 137 (02) : 186 - 188
[7] DUERCKHEIMER W, 1985, Angewandte Chemie International Edition in English, V24, P180
[8] PALLADIUM CATALYSIS IN CEPHALOSPORIN CHEMISTRY - GENERAL METHODOLOGY FOR THE SYNTHESIS OF CEPHEM SIDE-CHAINS
FARINA, V
BAKER, SR
BENIGNI, DA
HAUCK, SI
SAPINO, C
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (23) : 5833 - 5847
[9] SYNTHESIS OF ALPHA-METHYLENE-BETA-LACTAMS
FLETCHER, SR
KAY, IT
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1978, (20) : 903 - 904
[10] TOC-39, A NOVEL PARENTERAL BROAD-SPECTRUM CEPHALOSPORIN WITH EXCELLENT ACTIVITY AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS
HANAKI, H
AKAGI, H
MASARU, Y
OTANI, T
HYODO, A
HIRAMATSU, K
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (05) : 1120 - 1126

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